Submitted: Protein Language Models Capture Structural and Functional Epistasis in a Zero-Shot Setting

Can protein language model predict protein fitness and spot protein epistasis without training on a new dataset? We put them to the test with real protein mutations—see what happens when deep learning meets experimental biology.
Lab members: Ananthan Nambiar, Sayantani B. Littlefield, Carlos Cuellar, Rohit Khorana, Sergei Maslov
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